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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CTSG

Gene description

Cathepsin G

Protein class

Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (bone marrow)
GTEx:Tissue enhanced (skin)
FANTOM5:Mixed

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in subsets of lymphoid and hematopoietic cells.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA047737 , CAB000110
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

CTSG (HGNC Symbol)

Synonyms

CG

Description

Cathepsin G (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

Chromosome

14

Cytoband

q12

Chromosome location (bp)

24573522 - 24576260

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100448 (version 83.38)

Entrez gene

1511

UniProt

P08311 (UniProt - Evidence at protein level)

neXtProt

NX_P08311

Antibodypedia

CTSG antibodies

PROTEIN BROWSER

CTSG-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSG-001
ENSP00000216336
ENST00000216336
P08311 [Direct mapping]
Cathepsin G
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002003 [angiotensin maturation]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006508 [proteolysis]
GO:0006955 [immune response]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0009986 [cell surface]
GO:0016485 [protein processing]
GO:0022617 [extracellular matrix disassembly]
GO:0030141 [secretory granule]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0032496 [response to lipopolysaccharide]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0044267 [cellular protein metabolic process]
GO:0050778 [positive regulation of immune response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050832 [defense response to fungus]
GO:0070062 [extracellular exosome]
GO:0070946 [neutrophil mediated killing of gram-positive bacterium]
Show all
255 aa
28.8 kDa
Yes 0

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