Expression of CDKL1 in cancer - Summary

CANCER ATLAS

Gene description

Cyclin-dependent kinase-like 1 (CDC2-related kinase)

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA059605

GENE INFORMATION
Gene name	CDKL1 (HGNC Symbol)
Synonyms	KKIALRE
Description	Cyclin-dependent kinase-like 1 (CDC2-related kinase) (HGNC Symbol)
Entrez gene summary	This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Chromosome	14
Cytoband
Chromosome location (bp)	50329404 - 50416461
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100490 (version 83.38)
Entrez gene	8814
UniProt	Q00532 (UniProt - Evidence at protein level)
neXtProt	NX_Q00532
Antibodypedia	CDKL1 antibodies

PROTEIN BROWSER

CDKL1-001	CDKL1-003	CDKL1-009	CDKL1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDKL1-001 ENSP00000379176 ENST00000395834	Q00532 [Direct mapping] Cyclin-dependent kinase-like 1 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007507 [heart development] GO:0051726 [regulation of cell cycle] GO:0070062 [extracellular exosome] Show all	358 aa 41.8 kDa	No	0
CDKL1-003 ENSP00000216378 ENST00000216378	J3KMW1 [Direct mapping] Cyclin-dependent kinase-like 1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	276 aa 31.9 kDa	No	0
CDKL1-009 ENSP00000435044 ENST00000534267	H0YE65 [Direct mapping] Cyclin-dependent kinase-like 1 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	140 aa 16 kDa	No	0
CDKL1-010 ENSP00000431449 ENST00000525911	H0YCE5 [Direct mapping] Cyclin-dependent kinase-like 1 Show all	Predicted intracellular proteins Show all		70 aa 7.9 kDa	No	0