Cell atlas - CDKL1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CDKL1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CDKL1
Gene description	Cyclin-dependent kinase-like 1 (CDC2-related kinase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated), Vesicles (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA059605 , HPA065919
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (validated), Vesicles (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA059605	A-431	Nucleoplasm
HPA059605	A-431	Vesicles
HPA059605	U-2 OS	No staining
HPA065919	A-431	Nucleoplasm
HPA065919	A-431	Vesicles
HPA065919	CACO-2	Nucleoplasm
HPA065919	CACO-2	Vesicles
HPA065919	U-2 OS	Nucleoplasm
HPA065919	U-2 OS	Vesicles

GENE INFORMATION
Gene name	CDKL1 (HGNC Symbol)
Synonyms	KKIALRE
Description	Cyclin-dependent kinase-like 1 (CDC2-related kinase) (HGNC Symbol)
Entrez gene summary	This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Chromosome	14
Cytoband
Chromosome location (bp)	50329404 - 50416461
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100490 (version 83.38)
Entrez gene	8814
UniProt	Q00532 (UniProt - Evidence at protein level)
neXtProt	NX_Q00532
Antibodypedia	CDKL1 antibodies

PROTEIN BROWSER

CDKL1-001	CDKL1-003	CDKL1-009	CDKL1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDKL1-001 ENSP00000379176 ENST00000395834	Q00532 [Direct mapping] Cyclin-dependent kinase-like 1 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007507 [heart development] GO:0051726 [regulation of cell cycle] GO:0070062 [extracellular exosome] Show all	358 aa 41.8 kDa	No	0
CDKL1-003 ENSP00000216378 ENST00000216378	J3KMW1 [Direct mapping] Cyclin-dependent kinase-like 1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	276 aa 31.9 kDa	No	0
CDKL1-009 ENSP00000435044 ENST00000534267	H0YE65 [Direct mapping] Cyclin-dependent kinase-like 1 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	140 aa 16 kDa	No	0
CDKL1-010 ENSP00000431449 ENST00000525911	H0YCE5 [Direct mapping] Cyclin-dependent kinase-like 1 Show all	Predicted intracellular proteins Show all		70 aa 7.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.