Tissue expression of ATP6V1D - Summary - The Human Protein Atlas

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ATP6V1D

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ATP6V1D
Gene description	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

High cytoplasmic and membranous expression in renal tubules and neuropil in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA031515 , HPA057316
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ATP6V1D (HGNC Symbol)
Synonyms	ATP6M, VATD, VMA8
Description	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D (HGNC Symbol)
Entrez gene summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q23.3
Chromosome location (bp)	67294371 - 67360265
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100554 (version 83.38)
Entrez gene	51382
UniProt	Q9Y5K8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5K8
Antibodypedia	ATP6V1D antibodies

PROTEIN BROWSER

ATP6V1D-001	ATP6V1D-002	ATP6V1D-005	ATP6V1D-006	ATP6V1D-010	ATP6V1D-013	ATP6V1D-014	ATP6V1D-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6V1D-001 ENSP00000216442 ENST00000216442	Q9Y5K8 [Direct mapping] V-type proton ATPase subunit D A0A024R683 [Target identity:100%; Query identity:100%] ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005929 [cilium] GO:0006879 [cellular iron ion homeostasis] GO:0008286 [insulin receptor signaling pathway] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0033176 [proton-transporting V-type ATPase complex] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0042384 [cilium assembly] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0061512 [protein localization to cilium] GO:0070062 [extracellular exosome] GO:0090382 [phagosome maturation] Show all	247 aa 28.3 kDa	No	0
ATP6V1D-002 ENSP00000450885 ENST00000555474	G3V2V6 [Direct mapping] V-type proton ATPase subunit D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	148 aa 17.4 kDa	No	0
ATP6V1D-005 ENSP00000451031 ENST00000555012	G3V341 [Direct mapping] V-type proton ATPase subunit D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	72 aa 8.2 kDa	No	0
ATP6V1D-006 ENSP00000452492 ENST00000553687	G3V5S7 [Direct mapping] V-type proton ATPase subunit D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	59 aa 6.6 kDa	No	0
ATP6V1D-010 ENSP00000450834 ENST00000553408	H0YJ55 [Direct mapping] V-type proton ATPase subunit D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	44 aa 4.7 kDa	No	0
ATP6V1D-013 ENSP00000452192 ENST00000554236	G3V559 [Direct mapping] V-type proton ATPase subunit D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	179 aa 19.9 kDa	No	0
ATP6V1D-014 ENSP00000450841 ENST00000555431	G3V2S6 [Direct mapping] V-type proton ATPase subunit D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	192 aa 21.9 kDa	No	0
ATP6V1D-015 ENSP00000452029 ENST00000555723	H0YJS0 [Direct mapping] V-type proton ATPase subunit D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	119 aa 13.2 kDa	No	0

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