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Cases of carcinoids, ovarian, lung, testis and liver cancers showed moderate to strong cytoplasmic staining while several prostate, breast, melanomas and pancreatic cancers displayed moderate positivity. Cancer cells in general were weakly stained or negative.
Cancer tissues showed moderate cytoplasmic staining, often with a granular pattern. Several cases of melanomas, gliomas, papillary adenocarcinomas of thyroid, seminomas along with few cases of breast and endometrial cancers displayed strong immunoreactivity. Few cases of skin cancers showed additional nucleolar staining.
GENE INFORMATION
Gene name
VTI1B (HGNC Symbol)
Synonyms
VTI2
Description
Vesicle transport through interaction with t-SNAREs 1B (HGNC Symbol)