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The majority of malignant tissues displayed weak to moderate cytoplasmic immunoreactivity. A few cases of endometrial, liver and lung cancers exhibited strong nuclear staining. Malignant gliomas and lymphomas along with several cases of cervical and urothelial cancers were negative.
GENE INFORMATION
Gene name
ISM2 (HGNC Symbol)
Synonyms
FLJ32147, TAIL1, THSD3
Description
Isthmin 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Mar 2009]
