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ISM2

GENERAL INFORMATION

Gene name

 ISM2

Gene description

 Isthmin 2

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (placenta)
GTEx:Tissue enhanced (prostate, testis)
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of cells in placenta.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA039314 , HPA039742
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 ISM2 (HGNC Symbol)

Synonyms

 FLJ32147, TAIL1, THSD3

Description

 Isthmin 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Mar 2009]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 77474394 - 77498850

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100593 (version 83.38)

Entrez gene

 145501

UniProt

 Q6H9L7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q6H9L7

Antibodypedia

 ISM2 antibodies

PROTEIN BROWSER
ISM2-001
ISM2-003
ISM2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ISM2-001
ENSP00000341490
ENST00000342219
Q6H9L7 [Direct mapping]
Isthmin-2
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
Show all
 571 aa
63.9 kDa 		Yes 0
ISM2-003
ENSP00000420452
ENST00000493585
Q6H9L7 [Direct mapping]
Isthmin-2
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
Show all
 292 aa
31.3 kDa 		Yes 0
ISM2-008
ENSP00000450791
ENST00000554801
G3V2Q2 [Direct mapping]
Isthmin-2
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 185 aa
20.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.