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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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SIX4
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

SIX homeobox 4

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA031794

Tissue

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Tissue

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Weak to moderate immunoreactivity was observed in colorectal, breast, prostate, cervical, skin, urothelial and liver cancers. Remaining cancers were mainly negative.

GENE INFORMATION

Gene name

SIX4 (HGNC Symbol)

Synonyms

AREC3

Description

SIX homeobox 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010]

Chromosome

14

Cytoband

q23.1

Chromosome location (bp)

60709528 - 60724348

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100625 (version 83.38)

Entrez gene

51804

UniProt

Q9UIU6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UIU6

Antibodypedia

SIX4 antibodies

PROTEIN BROWSER

SIX4-001
SIX4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIX4-001
ENSP00000216513
ENST00000216513
Q9UIU6 [Direct mapping]
Homeobox protein SIX4
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007519 [skeletal muscle tissue development]
GO:0008582 [regulation of synaptic growth at neuromuscular junction]
GO:0008584 [male gonad development]
GO:0009653 [anatomical structure morphogenesis]
GO:0010468 [regulation of gene expression]
GO:0030238 [male sex determination]
GO:0030910 [olfactory placode formation]
GO:0032880 [regulation of protein localization]
GO:0034504 [protein localization to nucleus]
GO:0042472 [inner ear morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043586 [tongue development]
GO:0045214 [sarcomere organization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046661 [male sex differentiation]
GO:0048538 [thymus development]
GO:0048699 [generation of neurons]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0048856 [anatomical structure development]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0051451 [myoblast migration]
GO:0060037 [pharyngeal system development]
GO:0061055 [myotome development]
GO:0061197 [fungiform papilla morphogenesis]
GO:0061551 [trigeminal ganglion development]
GO:0072075 [metanephric mesenchyme development]
GO:0072095 [regulation of branch elongation involved in ureteric bud branching]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0098528 [skeletal muscle fiber differentiation]
GO:1902725 [negative regulation of satellite cell differentiation]
Show all
781 aa
82.9 kDa
No 0
SIX4-004
ENSP00000450761
ENST00000556952
G3V2N2 [Direct mapping]
Homeobox protein SIX4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
494 aa
52.7 kDa
No 0

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