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This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007519 [skeletal muscle tissue development] GO:0008582 [regulation of synaptic growth at neuromuscular junction] GO:0008584 [male gonad development] GO:0009653 [anatomical structure morphogenesis] GO:0010468 [regulation of gene expression] GO:0030238 [male sex determination] GO:0030910 [olfactory placode formation] GO:0032880 [regulation of protein localization] GO:0034504 [protein localization to nucleus] GO:0042472 [inner ear morphogenesis] GO:0043066 [negative regulation of apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0043586 [tongue development] GO:0045214 [sarcomere organization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046661 [male sex differentiation] GO:0048538 [thymus development] GO:0048699 [generation of neurons] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048856 [anatomical structure development] GO:0050678 [regulation of epithelial cell proliferation] GO:0051451 [myoblast migration] GO:0060037 [pharyngeal system development] GO:0061055 [myotome development] GO:0061197 [fungiform papilla morphogenesis] GO:0061551 [trigeminal ganglion development] GO:0072075 [metanephric mesenchyme development] GO:0072095 [regulation of branch elongation involved in ureteric bud branching] GO:0072107 [positive regulation of ureteric bud formation] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0098528 [skeletal muscle fiber differentiation] GO:1902725 [negative regulation of satellite cell differentiation]