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TCL1A

GENERAL INFORMATION

Gene name

 TCL1A

Gene description

 T-cell leukemia/lymphoma 1A

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, tonsil)
GTEx:Group enriched (spleen, testis, small intestine)
FANTOM5:Group enriched (appendix, tonsil, spleen, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct nuclear and cytoplasmic expression in subsets of immune cells in the mantle zone.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA016604 , CAB004045
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, testis, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, tonsil, spleen, lymph node)

GENE INFORMATION

Gene name

 TCL1A (HGNC Symbol)

Synonyms

 TCL1

Description

 T-cell leukemia/lymphoma 1A (HGNC Symbol)

Entrez gene summary

 Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

Chromosome

 14

Cytoband

 q32.13

Chromosome location (bp)

 95709967 - 95714196

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100721 (version 83.38)

Entrez gene

 8115

UniProt

 P56279 (UniProt - Evidence at protein level)

neXtProt

 NX_P56279

Antibodypedia

 TCL1A antibodies

PROTEIN BROWSER
TCL1A-001
TCL1A-002
TCL1A-005
TCL1A-007
TCL1A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCL1A-001
ENSP00000451506
ENST00000554012
P56279 [Direct mapping]
T-cell leukemia/lymphoma protein 1A
A0A024R6G5 [Target identity:100%; Query identity:100%]
T-cell leukemia/lymphoma 1A, isoform CRA_b
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0007275 [multicellular organismal development]
Show all
 114 aa
13.5 kDa 		No 0
TCL1A-002
ENSP00000450496
ENST00000555202
P56279 [Direct mapping]
T-cell leukemia/lymphoma protein 1A
A0A024R6G5 [Target identity:100%; Query identity:100%]
T-cell leukemia/lymphoma 1A, isoform CRA_b
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0007275 [multicellular organismal development]
Show all
 114 aa
13.5 kDa 		No 0
TCL1A-005
ENSP00000450701
ENST00000556450
P56279 [Direct mapping]
T-cell leukemia/lymphoma protein 1A
A0A024R6G5 [Target identity:100%; Query identity:100%]
T-cell leukemia/lymphoma 1A, isoform CRA_b
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0007275 [multicellular organismal development]
Show all
 114 aa
13.5 kDa 		No 0
TCL1A-007
ENSP00000452028
ENST00000557043
H0YJR9 [Direct mapping]
T-cell leukemia/lymphoma protein 1A
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 53 aa
6.2 kDa 		No 0
TCL1A-201
ENSP00000385036
ENST00000402399
P56279 [Direct mapping]
T-cell leukemia/lymphoma protein 1A
A0A024R6G5 [Target identity:100%; Query identity:100%]
T-cell leukemia/lymphoma 1A, isoform CRA_b
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005938 [cell cortex]
GO:0007275 [multicellular organismal development]
GO:0010629 [negative regulation of gene expression]
GO:0019827 [stem cell population maintenance]
GO:0045120 [pronucleus]
GO:2000036 [regulation of stem cell population maintenance]
Show all
 114 aa
13.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.