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ARHGAP5

CANCER ATLAS

Gene description

 Rho GTPase activating protein 5

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA046993

GENE INFORMATION

Gene name

 ARHGAP5 (HGNC Symbol)

Synonyms

 GFI2, p190-B, p190BRhoGAP, RhoGAP5

Description

 Rho GTPase activating protein 5 (HGNC Symbol)

Entrez gene summary

 Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q12

Chromosome location (bp)

 32076114 - 32159728

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100852 (version 83.38)

Entrez gene

 394

UniProt

 Q13017 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13017

Antibodypedia

 ARHGAP5 antibodies

PROTEIN BROWSER
ARHGAP5-001
ARHGAP5-002
ARHGAP5-003
ARHGAP5-004
ARHGAP5-006
ARHGAP5-007
ARHGAP5-008
ARHGAP5-201
ARHGAP5-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP5-001
ENSP00000441692
ENST00000539826
Q13017 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0016020 [membrane]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1502 aa
172.5 kDa 		No 0
ARHGAP5-002
ENSP00000452222
ENST00000556611
Q13017 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0016020 [membrane]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1501 aa
172.3 kDa 		No 0
ARHGAP5-003
ENSP00000379827
ENST00000396582
Q13017 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0016020 [membrane]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 237 aa
27 kDa 		No 0
ARHGAP5-004
ENSP00000407395
ENST00000433497
Q13017 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0016020 [membrane]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 241 aa
27.4 kDa 		No 0
ARHGAP5-006
ENSP00000452372
ENST00000555814
G3V5I7 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 37 aa
3.9 kDa 		No 0
ARHGAP5-007
ENSP00000451579
ENST00000556191
G3V444 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 140 aa
15.8 kDa 		No 0
ARHGAP5-008
ENSP00000451061
ENST00000554090
G3V360 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 137 aa
15.6 kDa 		No 0
ARHGAP5-201
ENSP00000371897
ENST00000345122
Q13017 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0008361 [regulation of cell size]
GO:0016020 [membrane]
GO:0030335 [positive regulation of cell migration]
GO:0030879 [mammary gland development]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1502 aa
172.5 kDa 		No 0
ARHGAP5-202
ENSP00000393307
ENST00000432921
A0A0A0MSK6 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 1498 aa
171.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.