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ARHGAP5

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GENERAL INFORMATION

Gene name

 ARHGAP5

Gene description

 Rho GTPase activating protein 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & endoplasmic reticulum.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Endoplasmic reticulum (approved), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA056507
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & endoplasmic reticulum.

Main location

 Endoplasmic reticulum (approved), Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA056507 A-431 Endoplasmic reticulum
Cytosol
HPA056507 A549 Endoplasmic reticulum
Cytosol

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000035133 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA056507 NIH 3T3 No staining

GENE INFORMATION

Gene name

 ARHGAP5 (HGNC Symbol)

Synonyms

 GFI2, p190-B, p190BRhoGAP, RhoGAP5

Description

 Rho GTPase activating protein 5 (HGNC Symbol)

Entrez gene summary

 Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q12

Chromosome location (bp)

 32076114 - 32159728

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100852 (version 83.38)

Entrez gene

 394

UniProt

 Q13017 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13017

Antibodypedia

 ARHGAP5 antibodies

PROTEIN BROWSER
ARHGAP5-001
ARHGAP5-002
ARHGAP5-003
ARHGAP5-004
ARHGAP5-006
ARHGAP5-007
ARHGAP5-008
ARHGAP5-201
ARHGAP5-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP5-001
ENSP00000441692
ENST00000539826
Q13017 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0016020 [membrane]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1502 aa
172.5 kDa 		No 0
ARHGAP5-002
ENSP00000452222
ENST00000556611
Q13017 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0016020 [membrane]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1501 aa
172.3 kDa 		No 0
ARHGAP5-003
ENSP00000379827
ENST00000396582
Q13017 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0016020 [membrane]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 237 aa
27 kDa 		No 0
ARHGAP5-004
ENSP00000407395
ENST00000433497
Q13017 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0016020 [membrane]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 241 aa
27.4 kDa 		No 0
ARHGAP5-006
ENSP00000452372
ENST00000555814
G3V5I7 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 37 aa
3.9 kDa 		No 0
ARHGAP5-007
ENSP00000451579
ENST00000556191
G3V444 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 140 aa
15.8 kDa 		No 0
ARHGAP5-008
ENSP00000451061
ENST00000554090
G3V360 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 137 aa
15.6 kDa 		No 0
ARHGAP5-201
ENSP00000371897
ENST00000345122
Q13017 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0008361 [regulation of cell size]
GO:0016020 [membrane]
GO:0030335 [positive regulation of cell migration]
GO:0030879 [mammary gland development]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1502 aa
172.5 kDa 		No 0
ARHGAP5-202
ENSP00000393307
ENST00000432921
A0A0A0MSK6 [Direct mapping]
Rho GTPase-activating protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 1498 aa
171.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.