We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007253 [cytoplasmic sequestering of NF-kappaB] GO:0008134 [transcription factor binding] GO:0008139 [nuclear localization sequence binding] GO:0010468 [regulation of gene expression] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010875 [positive regulation of cholesterol efflux] GO:0010888 [negative regulation of lipid storage] GO:0016032 [viral process] GO:0019899 [enzyme binding] GO:0031072 [heat shock protein binding] GO:0031625 [ubiquitin protein ligase binding] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032403 [protein complex binding] GO:0032481 [positive regulation of type I interferon production] GO:0032495 [response to muramyl dipeptide] GO:0032496 [response to lipopolysaccharide] GO:0033256 [I-kappaB/NF-kappaB complex] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035994 [response to muscle stretch] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042345 [regulation of NF-kappaB import into nucleus] GO:0042802 [identical protein binding] GO:0042994 [cytoplasmic sequestering of transcription factor] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043330 [response to exogenous dsRNA] GO:0043392 [negative regulation of DNA binding] GO:0045087 [innate immune response] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045746 [negative regulation of Notch signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050852 [T cell receptor signaling pathway] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070417 [cellular response to cold] GO:0070427 [nucleotide-binding oligomerization domain containing 1 signaling pathway] GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071345 [cellular response to cytokine stimulus] GO:0071407 [cellular response to organic cyclic compound]