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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NFKBIA

Gene description

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA029207 , CAB003815
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

NFKBIA (HGNC Symbol)

Synonyms

IkappaBalpha, IKBA, MAD-3, NFKBI

Description

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

Chromosome

14

Cytoband

q13.2

Chromosome location (bp)

35401511 - 35404749

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100906 (version 83.38)

Entrez gene

4792

UniProt

P25963 (UniProt - Evidence at protein level)

neXtProt

NX_P25963

Antibodypedia

NFKBIA antibodies

PROTEIN BROWSER

NFKBIA-001
NFKBIA-002
NFKBIA-004
NFKBIA-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFKBIA-001
ENSP00000216797
ENST00000216797
P25963 [Direct mapping]
NF-kappa-B inhibitor alpha
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007253 [cytoplasmic sequestering of NF-kappaB]
GO:0008134 [transcription factor binding]
GO:0008139 [nuclear localization sequence binding]
GO:0010468 [regulation of gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010888 [negative regulation of lipid storage]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0031072 [heat shock protein binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032403 [protein complex binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0032495 [response to muramyl dipeptide]
GO:0032496 [response to lipopolysaccharide]
GO:0033256 [I-kappaB/NF-kappaB complex]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035994 [response to muscle stretch]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042345 [regulation of NF-kappaB import into nucleus]
GO:0042802 [identical protein binding]
GO:0042994 [cytoplasmic sequestering of transcription factor]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043330 [response to exogenous dsRNA]
GO:0043392 [negative regulation of DNA binding]
GO:0045087 [innate immune response]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051059 [NF-kappaB binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070417 [cellular response to cold]
GO:0070427 [nucleotide-binding oligomerization domain containing 1 signaling pathway]
GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071407 [cellular response to organic cyclic compound]
Show all
317 aa
35.6 kDa
No 0
NFKBIA-002
ENSP00000451257
ENST00000557140
G3V3I4 [Direct mapping]
NF-kappa-B inhibitor alpha
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
274 aa
30.9 kDa
No 0
NFKBIA-004
ENSP00000450514
ENST00000557389
G3V286 [Direct mapping]
NF-kappa-B inhibitor alpha
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
227 aa
25 kDa
No 0
NFKBIA-011
ENSP00000451281
ENST00000553342
G3V3K1 [Direct mapping]
NF-kappa-B inhibitor alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
69 aa
8.1 kDa
No 0

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The Human Protein Atlas project is funded
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