Expression of GSS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glutathione synthetase

Protein class

Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA054508	HPA059315

GENE INFORMATION
Gene name	GSS
Synonyms
Description	Glutathione synthetase (HGNC Symbol)
Entrez gene summary	Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q11.22
Chromosome location (bp)	34928430 - 34955817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100983 (version 83.38)
Entrez gene	2937
UniProt	P48637 (UniProt - Evidence at protein level)
neXtProt	NX_P48637
Antibodypedia	GSS antibodies

PROTEIN BROWSER

GSS-001	GSS-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GSS-001 ENSP00000216951 ENST00000216951	P48637 [Direct mapping] Glutathione synthetase V9HWJ1 [Target identity:100%; Query identity:100%] Glutathione synthetase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004363 [glutathione synthase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006520 [cellular amino acid metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0006979 [response to oxidative stress] GO:0007399 [nervous system development] GO:0007568 [aging] GO:0009410 [response to xenobiotic stimulus] GO:0016594 [glycine binding] GO:0031667 [response to nutrient levels] GO:0034612 [response to tumor necrosis factor] GO:0042277 [peptide binding] GO:0042803 [protein homodimerization activity] GO:0043200 [response to amino acid] GO:0043295 [glutathione binding] GO:0044281 [small molecule metabolic process] GO:0046686 [response to cadmium ion] GO:0070062 [extracellular exosome] GO:1901687 [glutathione derivative biosynthetic process] Show all	474 aa 52.4 kDa	No	0
GSS-201 ENSP00000407517 ENST00000451957	P48637 [Direct mapping] Glutathione synthetase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004363 [glutathione synthase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006520 [cellular amino acid metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0006979 [response to oxidative stress] GO:0007399 [nervous system development] GO:0042803 [protein homodimerization activity] GO:0043295 [glutathione binding] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] GO:1901687 [glutathione derivative biosynthetic process] Show all	363 aa 40.3 kDa	No	0