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GSS

GENERAL INFORMATION

Gene name

 GSS

Gene description

 Glutathione synthetase

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA054508 , HPA059315
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GSS

Synonyms

Description

 Glutathione synthetase (HGNC Symbol)

Entrez gene summary

 Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.22

Chromosome location (bp)

 34928430 - 34955817

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100983 (version 83.38)

Entrez gene

 2937

UniProt

 P48637 (UniProt - Evidence at protein level)

neXtProt

 NX_P48637

Antibodypedia

 GSS antibodies

PROTEIN BROWSER
GSS-001
GSS-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GSS-001
ENSP00000216951
ENST00000216951
P48637 [Direct mapping]
Glutathione synthetase
V9HWJ1 [Target identity:100%; Query identity:100%]
Glutathione synthetase
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004363 [glutathione synthase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006520 [cellular amino acid metabolic process]
GO:0006750 [glutathione biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006979 [response to oxidative stress]
GO:0007399 [nervous system development]
GO:0007568 [aging]
GO:0009410 [response to xenobiotic stimulus]
GO:0016594 [glycine binding]
GO:0031667 [response to nutrient levels]
GO:0034612 [response to tumor necrosis factor]
GO:0042277 [peptide binding]
GO:0042803 [protein homodimerization activity]
GO:0043200 [response to amino acid]
GO:0043295 [glutathione binding]
GO:0044281 [small molecule metabolic process]
GO:0046686 [response to cadmium ion]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 474 aa
52.4 kDa 		No 0
GSS-201
ENSP00000407517
ENST00000451957
P48637 [Direct mapping]
Glutathione synthetase
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004363 [glutathione synthase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006520 [cellular amino acid metabolic process]
GO:0006750 [glutathione biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006979 [response to oxidative stress]
GO:0007399 [nervous system development]
GO:0042803 [protein homodimerization activity]
GO:0043295 [glutathione binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 363 aa
40.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.