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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001501 [skeletal system development] GO:0001503 [ossification] GO:0001934 [positive regulation of protein phosphorylation] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007411 [axon guidance] GO:0007566 [embryo implantation] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030225 [macrophage differentiation] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0042802 [identical protein binding] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051549 [positive regulation of keratinocyte migration] GO:0070062 [extracellular exosome] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:1900122 [positive regulation of receptor binding] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001258 [negative regulation of cation channel activity] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]