Cell atlas - BIRC7 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BIRC7
Gene description	Baculoviral IAP repeat containing 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol & microtubule organizing center.
RNA cell category	Cell line enhanced (SK-MEL-30, U-937, REH)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Microtubule organizing center (uncertain), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA047850
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30, U-937, REH) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol & microtubule organizing center.

Main location

Nucleus (supported)

Additional location

Microtubule organizing center (uncertain), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA047850	CACO-2	No staining
HPA047850	SK-MEL-30	Nucleoplasm
HPA047850	SK-MEL-30	Cytosol
HPA047850	U-2 OS	Nucleus
HPA047850	U-2 OS	Microtubule organizing center

GENE INFORMATION
Gene name	BIRC7 (HGNC Symbol)
Synonyms	KIAP, ML-IAP, mliap, RNF50
Description	Baculoviral IAP repeat containing 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	63235883 - 63240507
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101197 (version 83.38)
Entrez gene	79444
UniProt	Q96CA5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96CA5
Antibodypedia	BIRC7 antibodies

PROTEIN BROWSER

BIRC7-001	BIRC7-002	BIRC7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BIRC7-001 ENSP00000345213 ENST00000342412	Q96CA5 [Direct mapping] Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30kDa subunit Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007257 [activation of JUN kinase activity] GO:0008270 [zinc ion binding] GO:0009966 [regulation of signal transduction] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0042127 [regulation of cell proliferation] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0070247 [regulation of natural killer cell apoptotic process] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] Show all	280 aa 30.9 kDa	No	0
BIRC7-002 ENSP00000217169 ENST00000217169	Q96CA5 [Direct mapping] Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30kDa subunit Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007257 [activation of JUN kinase activity] GO:0008270 [zinc ion binding] GO:0009966 [regulation of signal transduction] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0042127 [regulation of cell proliferation] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0070247 [regulation of natural killer cell apoptotic process] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] Show all	298 aa 32.8 kDa	No	0
BIRC7-003 ENSP00000378717 ENST00000395306	A8MTF4 [Direct mapping] Baculoviral IAP repeat-containing protein 7 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0009966 [regulation of signal transduction] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] Show all	193 aa 21.4 kDa	No	0