Tissue expression of BIRC7 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BIRC7
Gene description	Baculoviral IAP repeat containing 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta)
GTEx:	Mixed
FANTOM5:	Group enriched (retina, epididymis, placenta)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (retina, epididymis, placenta)

GENE INFORMATION
Gene name	BIRC7 (HGNC Symbol)
Synonyms	KIAP, ML-IAP, mliap, RNF50
Description	Baculoviral IAP repeat containing 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	63235883 - 63240507
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101197 (version 83.38)
Entrez gene	79444
UniProt	Q96CA5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96CA5
Antibodypedia	BIRC7 antibodies

PROTEIN BROWSER

BIRC7-001	BIRC7-002	BIRC7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BIRC7-001 ENSP00000345213 ENST00000342412	Q96CA5 [Direct mapping] Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30kDa subunit Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007257 [activation of JUN kinase activity] GO:0008270 [zinc ion binding] GO:0009966 [regulation of signal transduction] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0042127 [regulation of cell proliferation] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0070247 [regulation of natural killer cell apoptotic process] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] Show all	280 aa 30.9 kDa	No	0
BIRC7-002 ENSP00000217169 ENST00000217169	Q96CA5 [Direct mapping] Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30kDa subunit Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007257 [activation of JUN kinase activity] GO:0008270 [zinc ion binding] GO:0009966 [regulation of signal transduction] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0042127 [regulation of cell proliferation] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0070247 [regulation of natural killer cell apoptotic process] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] Show all	298 aa 32.8 kDa	No	0
BIRC7-003 ENSP00000378717 ENST00000395306	A8MTF4 [Direct mapping] Baculoviral IAP repeat-containing protein 7 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0009966 [regulation of signal transduction] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] Show all	193 aa 21.4 kDa	No	0