Expression of NDUFAF5 in cancer - Summary

CANCER ATLAS

Gene description

NADH dehydrogenase (ubiquinone) complex I, assembly factor 5

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051184

GENE INFORMATION
Gene name	NDUFAF5 (HGNC Symbol)
Synonyms	C20orf7, dJ842G6.1
Description	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 (HGNC Symbol)
Entrez gene summary	The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes a mitochondrial protein that is associated with the matrix face of the mitochondrial inner membrane and is required for complex I assembly. A mutation in this gene results in mitochondrial complex I deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	20
Cytoband	p12.1
Chromosome location (bp)	13784950 - 13821582
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101247 (version 83.38)
Entrez gene	79133
UniProt	Q5TEU4 (UniProt - Evidence at protein level)
neXtProt	NX_Q5TEU4
Antibodypedia	NDUFAF5 antibodies

PROTEIN BROWSER

NDUFAF5-006	NDUFAF5-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFAF5-006 ENSP00000367346 ENST00000378106	Q5TEU4 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0008152 [metabolic process] GO:0008168 [methyltransferase activity] GO:0022904 [respiratory electron transport chain] GO:0031314 [extrinsic component of mitochondrial inner membrane] GO:0032259 [methylation] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	345 aa 38.9 kDa	No	0
NDUFAF5-008 ENSP00000420497 ENST00000463598	Q5TEU4 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005743 [mitochondrial inner membrane] GO:0008168 [methyltransferase activity] GO:0022904 [respiratory electron transport chain] GO:0031314 [extrinsic component of mitochondrial inner membrane] GO:0032259 [methylation] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	317 aa 36.1 kDa	No	0