Expression of HM13 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Histocompatibility (minor) 13

Protein class

Enzymes, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045089

GENE INFORMATION
Gene name	HM13 (HGNC Symbol)
Synonyms	dJ324O17.1, H13, IMP1, IMPAS, PSENL3, PSL3, SPP, SPPL1
Description	Histocompatibility (minor) 13 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q11.21
Chromosome location (bp)	31514428 - 31577923
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101294 (version 83.38)
Entrez gene	81502
UniProt	Q8TCT9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCT9
Antibodypedia	HM13 antibodies

PROTEIN BROWSER

HM13-009	HM13-011	HM13-012	HM13-013	HM13-014	HM13-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HM13-009 ENSP00000335294 ENST00000335574	Q8TCT9 [Direct mapping] Minor histocompatibility antigen H13 Show all	Enzymes Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005791 [rough endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0008233 [peptidase activity] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0033619 [membrane protein proteolysis] GO:0036513 [Derlin-1 retrotranslocation complex] GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving] GO:0042803 [protein homodimerization activity] GO:0051289 [protein homotetramerization] GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:1904211 [membrane protein proteolysis involved in retrograde protein transport, ER to cytosol] Show all	394 aa 43.4 kDa	No	9
HM13-011 ENSP00000343032 ENST00000340852	Q8TCT9 [Direct mapping] Minor histocompatibility antigen H13 Show all	Enzymes Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005791 [rough endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0008233 [peptidase activity] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0033619 [membrane protein proteolysis] GO:0036513 [Derlin-1 retrotranslocation complex] GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving] GO:0042803 [protein homodimerization activity] GO:0051289 [protein homotetramerization] GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:1904211 [membrane protein proteolysis involved in retrograde protein transport, ER to cytosol] Show all	377 aa 41.5 kDa	No	9
HM13-012 ENSP00000381237 ENST00000398174	Q8TCT9 [Direct mapping] Minor histocompatibility antigen H13 Show all	Enzymes Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005791 [rough endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0008233 [peptidase activity] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0033619 [membrane protein proteolysis] GO:0036513 [Derlin-1 retrotranslocation complex] GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving] GO:0042803 [protein homodimerization activity] GO:0051289 [protein homotetramerization] GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:1904211 [membrane protein proteolysis involved in retrograde protein transport, ER to cytosol] Show all	426 aa 46.8 kDa	No	9
HM13-013 ENSP00000479020 ENST00000498035	A0A0C4DGU3 [Direct mapping] Minor histocompatibility antigen H13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	143 aa 15.4 kDa	No	3
HM13-014 ENSP00000341347 ENST00000344042	A0A075B6F6 [Direct mapping] Minor histocompatibility antigen H13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	272 aa 30.2 kDa	No	6
HM13-027 ENSP00000479443 ENST00000619859	A0A087WVH6 [Direct mapping] Minor histocompatibility antigen H13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	50 aa 5.8 kDa	No	1