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MYLK2

GENERAL INFORMATION

Gene name

 MYLK2

Gene description

 Myosin light chain kinase 2

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skeletal muscle)
GTEx:Tissue enriched (skeletal muscle)
FANTOM5:Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA059704 , HPA059890
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION

Gene name

 MYLK2 (HGNC Symbol)

Synonyms

 KMLC, MLCK2, skMLCK

Description

 Myosin light chain kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 31819308 - 31834689

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101306 (version 83.38)

Entrez gene

 85366

UniProt

 Q9H1R3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H1R3

Antibodypedia

 MYLK2 antibodies

PROTEIN BROWSER
MYLK2-001
MYLK2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYLK2-001
ENSP00000365152
ENST00000375985
Q9H1R3 [Direct mapping]
Myosin light chain kinase 2, skeletal/cardiac muscle
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006941 [striated muscle contraction]
GO:0010628 [positive regulation of gene expression]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030017 [sarcomere]
GO:0032971 [regulation of muscle filament sliding]
GO:0035914 [skeletal muscle cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0055008 [cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 596 aa
64.7 kDa 		No 0
MYLK2-002
ENSP00000365162
ENST00000375994
Q9H1R3 [Direct mapping]
Myosin light chain kinase 2, skeletal/cardiac muscle
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006941 [striated muscle contraction]
GO:0007274 [neuromuscular synaptic transmission]
GO:0010628 [positive regulation of gene expression]
GO:0014816 [skeletal muscle satellite cell differentiation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030017 [sarcomere]
GO:0032971 [regulation of muscle filament sliding]
GO:0035914 [skeletal muscle cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0055008 [cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 596 aa
64.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.