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MYL9

GENERAL INFORMATION

Gene name

 MYL9

Gene description

 Myosin, light chain 9, regulatory

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in smooth muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA039262 , HPA045244 , HPA059197
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MYL9 (HGNC Symbol)

Synonyms

 LC20, MLC2, MRLC1, MYRL2

Description

 Myosin, light chain 9, regulatory (HGNC Symbol)

Entrez gene summary

 Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.23

Chromosome location (bp)

 36541484 - 36551447

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101335 (version 83.38)

Entrez gene

 10398

UniProt

 P24844 (UniProt - Evidence at protein level)

neXtProt

 NX_P24844

Antibodypedia

 MYL9 antibodies

PROTEIN BROWSER
MYL9-001
MYL9-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYL9-001
ENSP00000279022
ENST00000279022
P24844 [Direct mapping]
Myosin regulatory light polypeptide 9
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0006937 [regulation of muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008307 [structural constituent of muscle]
GO:0016460 [myosin II complex]
GO:0030018 [Z disc]
GO:0032036 [myosin heavy chain binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070527 [platelet aggregation]
Show all
 172 aa
19.8 kDa 		No 0
MYL9-002
ENSP00000217313
ENST00000346786
P24844 [Direct mapping]
Myosin regulatory light polypeptide 9
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0006937 [regulation of muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008307 [structural constituent of muscle]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070527 [platelet aggregation]
Show all
 118 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.