Cell atlas - MROH8 - The Human Protein Atlas

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MROH8

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MROH8
Gene description	Maestro heat-like repeat family member 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Mixed
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA060298
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA060298	A549	Nucleus	Intensity
	HPA060298	SH-SY5Y	Nucleus	Intensity
	HPA060298	SH-SY5Y	Cytosol

GENE INFORMATION
Gene name	MROH8 (HGNC Symbol)
Synonyms	C20orf131, C20orf132, dJ621N11.3, dJ621N11.4
Description	Maestro heat-like repeat family member 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the maestro heat-like repeat family. The exact function of this gene is not known, however, in a genome-wide association study using hippocampal atrophy as a quantitative trait, this gene has been associated with Alzheimer's disease (PMID:19668339). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	37101226 - 37179588
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000101353 (version 83.38)
Entrez gene	140699
UniProt	Q9H579 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H579
Antibodypedia	MROH8 antibodies

PROTEIN BROWSER

MROH8-001	MROH8-002	MROH8-003	MROH8-004	MROH8-006	MROH8-007	MROH8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MROH8-001 ENSP00000413544 ENST00000421643	Q9H579 [Direct mapping] Protein MROH8 Show all	Predicted intracellular proteins Show all	GO:0005488 [binding] Show all	600 aa 67.6 kDa	No	0
MROH8-002 ENSP00000389695 ENST00000434295	Q5JYR0 [Direct mapping] Protein MROH8 Show all	Predicted intracellular proteins Show all		34 aa 3.9 kDa	No	0
MROH8-003 ENSP00000339971 ENST00000343811	H0Y2W4 [Direct mapping] Protein MROH8 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] Show all	1069 aa 121.2 kDa	No	0
MROH8-004 ENSP00000400468 ENST00000422138	Q5JYQ9 [Direct mapping] Protein MROH8 Show all	Predicted intracellular proteins Show all		24 aa 2.8 kDa	No	0
MROH8-006 ENSP00000415930 ENST00000417458	H0Y7Y5 [Direct mapping] Protein MROH8 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] Show all	670 aa 76.7 kDa	No	0
MROH8-007 ENSP00000383290 ENST00000400440	H0Y3S5 [Direct mapping] Protein MROH8 Show all	Predicted intracellular proteins Show all	GO:0005488 [binding] Show all	629 aa 71 kDa	No	0
MROH8-201 ENSP00000383291 ENST00000400441	E7ETR9 [Direct mapping] Protein MROH8 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] Show all	946 aa 107.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.