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The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000077 [DNA damage checkpoint] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000278 [mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007283 [spermatogenesis] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0019901 [protein kinase binding] GO:0030900 [forebrain development] GO:0035189 [Rb-E2F complex] GO:0043276 [anoikis] GO:0043392 [negative regulation of DNA binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045599 [negative regulation of fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048255 [mRNA stabilization] GO:0051726 [regulation of cell cycle] GO:0070345 [negative regulation of fat cell proliferation] GO:0071398 [cellular response to fatty acid] GO:0071456 [cellular response to hypoxia] GO:0071466 [cellular response to xenobiotic stimulus] GO:0071930 [negative regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1990086 [lens fiber cell apoptotic process] GO:1990090 [cellular response to nerve growth factor stimulus] GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
