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MAP1LC3A

GENERAL INFORMATION

Gene name

 MAP1LC3A

Gene description

 Microtubule-associated protein 1 light chain 3 alpha

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in neuronal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Supported based on 4 antibodies.
HPA007649 , HPA052474 , HPA052484 , CAB037174
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MAP1LC3A (HGNC Symbol)

Synonyms

 ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3

Description

 Microtubule-associated protein 1 light chain 3 alpha (HGNC Symbol)

Entrez gene summary

 MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]

Chromosome

 20

Cytoband

 q11.22

Chromosome location (bp)

 34546854 - 34560345

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101460 (version 83.38)

Entrez gene

 84557

UniProt

 Q9H492 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H492

Antibodypedia

 MAP1LC3A antibodies

PROTEIN BROWSER
MAP1LC3A-001
MAP1LC3A-002
MAP1LC3A-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP1LC3A-001
ENSP00000363970
ENST00000374837
Q9H492 [Direct mapping]
Microtubule-associated proteins 1A/1B light chain 3A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008017 [microtubule binding]
GO:0008429 [phosphatidylethanolamine binding]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0031090 [organelle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044804 [nucleophagy]
GO:0061025 [membrane fusion]
Show all
 125 aa
14.5 kDa 		No 0
MAP1LC3A-002
ENSP00000353886
ENST00000360668
Q9H492 [Direct mapping]
Microtubule-associated proteins 1A/1B light chain 3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008017 [microtubule binding]
GO:0008429 [phosphatidylethanolamine binding]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0031090 [organelle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044804 [nucleophagy]
GO:0061025 [membrane fusion]
Show all
 121 aa
14.3 kDa 		No 0
MAP1LC3A-003
ENSP00000380821
ENST00000397709
Q9H492 [Direct mapping]
Microtubule-associated proteins 1A/1B light chain 3A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008017 [microtubule binding]
GO:0008429 [phosphatidylethanolamine binding]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0031090 [organelle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044804 [nucleophagy]
GO:0061025 [membrane fusion]
Show all
 121 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.