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RBBP8

CANCER ATLAS

Gene description

 Retinoblastoma binding protein 8

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039890

GENE INFORMATION

Gene name

 RBBP8 (HGNC Symbol)

Synonyms

 COM1, CtIP, RIM, SCKL2

Description

 Retinoblastoma binding protein 8 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q11.2

Chromosome location (bp)

 22798261 - 23026488

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101773 (version 83.38)

Entrez gene

 5932

UniProt

 Q99708 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99708

Antibodypedia

 RBBP8 antibodies

PROTEIN BROWSER
«
RBBP8-001
RBBP8-002
RBBP8-003
RBBP8-004
RBBP8-005
RBBP8-007
RBBP8-008
RBBP8-009
RBBP8-010
RBBP8-011
RBBP8-015
RBBP8-016
RBBP8-017
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBBP8-001
ENSP00000323050
ENST00000327155
Q99708 [Direct mapping]
DNA endonuclease RBBP8
A0A024RC34 [Target identity:100%; Query identity:100%]
Retinoblastoma binding protein 8, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000014 [single-stranded DNA endodeoxyribonuclease activity]
GO:0000075 [cell cycle checkpoint]
GO:0000077 [DNA damage checkpoint]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0010792 [DNA double-strand break processing involved in repair via single-strand annealing]
GO:0017053 [transcriptional repressor complex]
GO:0031572 [G2 DNA damage checkpoint]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 897 aa
101.9 kDa 		No 0
RBBP8-002
ENSP00000382630
ENST00000399725
Q99708 [Direct mapping]
DNA endonuclease RBBP8
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000014 [single-stranded DNA endodeoxyribonuclease activity]
GO:0000075 [cell cycle checkpoint]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0010792 [DNA double-strand break processing involved in repair via single-strand annealing]
GO:0017053 [transcriptional repressor complex]
GO:0031572 [G2 DNA damage checkpoint]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 867 aa
98.4 kDa 		No 0
RBBP8-003
ENSP00000382627
ENST00000399721
F6Q6H0 [Direct mapping]
DNA endonuclease RBBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
Show all
 580 aa
65.5 kDa 		No 0
RBBP8-004
ENSP00000382628
ENST00000399722
Q99708 [Direct mapping]
DNA endonuclease RBBP8
A0A024RC34 [Target identity:100%; Query identity:100%]
Retinoblastoma binding protein 8, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000014 [single-stranded DNA endodeoxyribonuclease activity]
GO:0000075 [cell cycle checkpoint]
GO:0000077 [DNA damage checkpoint]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0001835 [blastocyst hatching]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0010792 [DNA double-strand break processing involved in repair via single-strand annealing]
GO:0017053 [transcriptional repressor complex]
GO:0031572 [G2 DNA damage checkpoint]
GO:0032355 [response to estradiol]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 897 aa
101.9 kDa 		No 0
RBBP8-005
ENSP00000354024
ENST00000360790
I6L8A6 [Direct mapping]
DNA endonuclease RBBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000014 [single-stranded DNA endodeoxyribonuclease activity]
GO:0000077 [DNA damage checkpoint]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
Show all
 902 aa
102.6 kDa 		No 0
RBBP8-007
ENSP00000462390
ENST00000579124
J3KSA4 [Direct mapping]
DNA endonuclease RBBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 64 aa
7.3 kDa 		No 0
RBBP8-008
ENSP00000463738
ENST00000582354
J3QLW6 [Direct mapping]
DNA endonuclease RBBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 205 aa
24.1 kDa 		No 0
RBBP8-009
ENSP00000464284
ENST00000577588
J3QRM0 [Direct mapping]
DNA endonuclease RBBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3.1 kDa 		No 0
RBBP8-010
ENSP00000463439
ENST00000581819
J3QL93 [Direct mapping]
DNA endonuclease RBBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 84 aa
9.8 kDa 		No 0
RBBP8-011
ENSP00000464628
ENST00000583700
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 11 aa
1 kDa 		No 0
RBBP8-015
ENSP00000464691
ENST00000583057
J3QSH7 [Direct mapping]
DNA endonuclease RBBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 324 aa
37.4 kDa 		No 0
RBBP8-016
ENSP00000463544
ENST00000581687
J3QLH2 [Direct mapping]
DNA endonuclease RBBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000014 [single-stranded DNA endodeoxyribonuclease activity]
GO:0000077 [DNA damage checkpoint]
GO:0006281 [DNA repair]
Show all
 75 aa
8.9 kDa 		No 0
RBBP8-017
ENSP00000463310
ENST00000577445
J3QL00 [Direct mapping]
DNA endonuclease RBBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 160 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.