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ATG4A

GENERAL INFORMATION

Gene name

 ATG4A

Gene description

 Autophagy related 4A, cysteine peptidase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA036374
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ATG4A (HGNC Symbol)

Synonyms

 APG4A, AUTL2

Description

 Autophagy related 4A, cysteine peptidase (HGNC Symbol)

Entrez gene summary

 Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q22.3

Chromosome location (bp)

 108091668 - 108154671

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101844 (version 83.38)

Entrez gene

 115201

UniProt

 Q8WYN0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WYN0

Antibodypedia

 ATG4A antibodies

PROTEIN BROWSER
ATG4A-001
ATG4A-002
ATG4A-005
ATG4A-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG4A-001
ENSP00000361306
ENST00000372232
Q8WYN0 [Direct mapping]
Cysteine protease ATG4A
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006508 [proteolysis]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008234 [cysteine-type peptidase activity]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 398 aa
45.4 kDa 		No 0
ATG4A-002
ENSP00000298131
ENST00000345734
Q8WYN0 [Direct mapping]
Cysteine protease ATG4A
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006508 [proteolysis]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008234 [cysteine-type peptidase activity]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 336 aa
38.6 kDa 		No 0
ATG4A-005
ENSP00000378354
ENST00000394892
H7BYM2 [Direct mapping]
Cysteine protease ATG4A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 312 aa
35.1 kDa 		No 0
ATG4A-006
ENSP00000416218
ENST00000457035
A0A0A0MT61 [Direct mapping]
Cysteine protease ATG4A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 202 aa
22.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.