Cell atlas - PGRMC1 - The Human Protein Atlas

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PGRMC1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Nucleoli

Human cell
	Endoplasmic Reticulum
	Nucleoli

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GENERAL INFORMATION
Gene name	PGRMC1
Gene description	Progesterone receptor membrane component 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli & endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA002877
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli & endoplasmic reticulum.

Main location

Nucleoli (approved), Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002877	A-431	Nucleoli
	HPA002877	A-431	Endoplasmic reticulum
	HPA002877	U-2 OS	Nucleoli
	HPA002877	U-2 OS	Endoplasmic reticulum
	HPA002877	U-251 MG	Nucleoli
	HPA002877	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	PGRMC1 (HGNC Symbol)
Synonyms	HPR6.6
Description	Progesterone receptor membrane component 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
Chromosome	X
Cytoband	q24
Chromosome location (bp)	119236245 - 119244466
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101856 (version 83.38)
Entrez gene	10857
UniProt	O00264 (UniProt - Evidence at protein level)
neXtProt	NX_O00264
Antibodypedia	PGRMC1 antibodies

PROTEIN BROWSER

PGRMC1-001	PGRMC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGRMC1-001 ENSP00000217971 ENST00000217971	O00264 [Direct mapping] Membrane-associated progesterone receptor component 1 Q6IB11 [Target identity:100%; Query identity:100%] PGRMC1 protein; Progesterone receptor membrane component 1; Progesterone receptor membrane component 1, isoform CRA_a; cDNA, FLJ94602, Homo sapiens progesterone receptor membrane component 1 (PGRMC1),mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0070062 [extracellular exosome] Show all	195 aa 21.7 kDa	No	1
PGRMC1-201 ENSP00000442821 ENST00000535419	O00264 [Direct mapping] Membrane-associated progesterone receptor component 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0070062 [extracellular exosome] Show all	143 aa 15.9 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.