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PGRMC1

GENERAL INFORMATION

Gene name

 PGRMC1

Gene description

 Progesterone receptor membrane component 1

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA002877
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PGRMC1 (HGNC Symbol)

Synonyms

 HPR6.6

Description

 Progesterone receptor membrane component 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 q24

Chromosome location (bp)

 119236245 - 119244466

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101856 (version 83.38)

Entrez gene

 10857

UniProt

 O00264 (UniProt - Evidence at protein level)

neXtProt

 NX_O00264

Antibodypedia

 PGRMC1 antibodies

PROTEIN BROWSER
PGRMC1-001
PGRMC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGRMC1-001
ENSP00000217971
ENST00000217971
O00264 [Direct mapping]
Membrane-associated progesterone receptor component 1
Q6IB11 [Target identity:100%; Query identity:100%]
PGRMC1 protein; Progesterone receptor membrane component 1; Progesterone receptor membrane component 1, isoform CRA_a; cDNA, FLJ94602, Homo sapiens progesterone receptor membrane component 1 (PGRMC1),mRNA
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0020037 [heme binding]
GO:0070062 [extracellular exosome]
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 195 aa
21.7 kDa 		No 1
PGRMC1-201
ENSP00000442821
ENST00000535419
O00264 [Direct mapping]
Membrane-associated progesterone receptor component 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0020037 [heme binding]
GO:0070062 [extracellular exosome]
Show all
 143 aa
15.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.