Expression of CCDC22 in cancer - Summary

CANCER ATLAS

Gene description

Coiled-coil domain containing 22

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA000888

GENE INFORMATION
Gene name	CCDC22 (HGNC Symbol)
Synonyms	CXorf37, JM1
Description	Coiled-coil domain containing 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	49235467 - 49250526
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101997 (version 83.38)
Entrez gene	28952
UniProt	O60826 (UniProt - Evidence at protein level)
neXtProt	NX_O60826
Antibodypedia	CCDC22 antibodies

PROTEIN BROWSER

CCDC22-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC22-001 ENSP00000365401 ENST00000376227	O60826 [Direct mapping] Coiled-coil domain-containing protein 22 A0A024QZ03 [Target identity:100%; Query identity:100%] Coiled-coil domain containing 22, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005768 [endosome] GO:0006878 [cellular copper ion homeostasis] GO:0006893 [Golgi to plasma membrane transport] GO:0007253 [cytoplasmic sequestering of NF-kappaB] GO:0015031 [protein transport] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0097602 [cullin family protein binding] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	627 aa 70.8 kDa	No	0