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CCDC22

GENERAL INFORMATION

Gene name

 CCDC22

Gene description

 Coiled-coil domain containing 22

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in parietal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA000888
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CCDC22 (HGNC Symbol)

Synonyms

 CXorf37, JM1

Description

 Coiled-coil domain containing 22 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 49235467 - 49250526

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101997 (version 83.38)

Entrez gene

 28952

UniProt

 O60826 (UniProt - Evidence at protein level)

neXtProt

 NX_O60826

Antibodypedia

 CCDC22 antibodies

PROTEIN BROWSER
CCDC22-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCDC22-001
ENSP00000365401
ENST00000376227
O60826 [Direct mapping]
Coiled-coil domain-containing protein 22
A0A024QZ03 [Target identity:100%; Query identity:100%]
Coiled-coil domain containing 22, isoform CRA_a
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005768 [endosome]
GO:0006878 [cellular copper ion homeostasis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0007253 [cytoplasmic sequestering of NF-kappaB]
GO:0015031 [protein transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0097602 [cullin family protein binding]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
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 627 aa
70.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.