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Cancers in general displayed weak immunoreactivity or were negative. A small fraction of malignant melanomas, testicular and hepatocellular cancers showed strong cytoplasmic staining.
GENE INFORMATION
Gene name
ASB9 (HGNC Symbol)
Synonyms
DKFZP564L0862, FLJ20636, MGC4954
Description
Ankyrin repeat and SOCS box containing 9 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]