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Cancer tissues showed weak to moderate nuclear membrane positivity. Several cases of melanomas and thyroid cancers along with a few cases of skin and urothelial cancers were strongly stained. A majority of lymphomas were negative.
Most cancer tissues displayed moderate to strong immunoreactivity of nuclear membranes. Several gliomas, lymphomas and testicular cancers were negative.
Cancer tissues displayed weak to moderate nuclear membranous and nuclear positivity with additional cytoplasmic staining in a few cases. Most of the thyroid, head and neck cancers along with cases of melanomas, lung, skin, colorectal and urothelial cancers were strongly stained. Majority of the cases of testicular, urothelial and prostate cancers were negative.
GENE INFORMATION
Gene name
EMD (HGNC Symbol)
Synonyms
LEMD5, STA
Description
Emerin (HGNC Symbol)
Entrez gene summary
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008]
