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KLHL4

CANCER ATLAS

Gene description

 Kelch-like family member 4

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029192

GENE INFORMATION

Gene name

 KLHL4 (HGNC Symbol)

Synonyms

 DKELCHL, KHL4, KIAA1687

Description

 Kelch-like family member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q21.31

Chromosome location (bp)

 87517749 - 87670050

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102271 (version 83.38)

Entrez gene

 56062

UniProt

 Q9C0H6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9C0H6

Antibodypedia

 KLHL4 antibodies

PROTEIN BROWSER
KLHL4-001
KLHL4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLHL4-001
ENSP00000362211
ENST00000373119
Q9C0H6 [Direct mapping]
Kelch-like protein 4
A5PKX1 [Target identity:100%; Query identity:100%]
Kelch-like 4 (Drosophila); Kelch-like 4 (Drosophila), isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003779 [actin binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008150 [biological_process]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
Show all
 718 aa
80.2 kDa 		No 0
KLHL4-002
ENSP00000362206
ENST00000373114
Q9C0H6 [Direct mapping]
Kelch-like protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003779 [actin binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008150 [biological_process]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
Show all
 720 aa
80.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.