Cell atlas - KLHL4 - The Human Protein Atlas

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KLHL4

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubule organizing center
	Microtubules

Human cell
	Centrosome
	Microtubules

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GENERAL INFORMATION
Gene name	KLHL4
Gene description	Kelch-like family member 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules. In addition localized to the microtubule organizing center.
RNA cell category	Cell line enhanced (TIME, HUVEC TERT2, NTERA-2, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (supported)
Additional location	In addition localized to the Microtubule organizing center (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA029192
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME, HUVEC TERT2, NTERA-2, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules. In addition localized to the microtubule organizing center.

Main location

Microtubules (supported)

Additional location

Microtubule organizing center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029192	PC-3	Microtubules
	HPA029192	RH-30	Microtubules
	HPA029192	RH-30	Microtubule organizing center
	HPA029192	U-2 OS	Microtubules

GENE INFORMATION
Gene name	KLHL4 (HGNC Symbol)
Synonyms	DKELCHL, KHL4, KIAA1687
Description	Kelch-like family member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q21.31
Chromosome location (bp)	87517749 - 87670050
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102271 (version 83.38)
Entrez gene	56062
UniProt	Q9C0H6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9C0H6
Antibodypedia	KLHL4 antibodies

PROTEIN BROWSER

KLHL4-001	KLHL4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHL4-001 ENSP00000362211 ENST00000373119	Q9C0H6 [Direct mapping] Kelch-like protein 4 A5PKX1 [Target identity:100%; Query identity:100%] Kelch-like 4 (Drosophila); Kelch-like 4 (Drosophila), isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0008150 [biological_process] GO:0016567 [protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] Show all	718 aa 80.2 kDa	No	0
KLHL4-002 ENSP00000362206 ENST00000373114	Q9C0H6 [Direct mapping] Kelch-like protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0008150 [biological_process] GO:0016567 [protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] Show all	720 aa 80.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.