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Cancer cancers showed weak to moderate cytoplasmic staining. Occasional cases of melanomas, breast, pancreatic and ovarian cancers displayed strong positivity.
Cancer tissue showed moderate to strong nuclear immunoreactivity with additional cytoplasmic positivity in several cases.
GENE INFORMATION
Gene name
DNAJC3 (HGNC Symbol)
Synonyms
HP58, P58, P58IPK, PRKRI
Description
DnaJ (Hsp40) homolog, subfamily C, member 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
Q13217 [Direct mapping] DnaJ homolog subfamily C member 3 A8KA82 [Target identity:100%; Query identity:100%] DnaJ (Hsp40) homolog, subfamily C, member 3; cDNA FLJ77657, highly similar to Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 3 (DNAJC3), mRNA; cDNA, FLJ93304, Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 3 (DNAJC3),mRNA
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004860 [protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005788 [endoplasmic reticulum lumen] GO:0005790 [smooth endoplasmic reticulum] GO:0016020 [membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0031205 [endoplasmic reticulum Sec complex] GO:0036498 [IRE1-mediated unfolded protein response] GO:0043066 [negative regulation of apoptotic process] GO:0044267 [cellular protein metabolic process] GO:0051087 [chaperone binding] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0051607 [defense response to virus] GO:0051787 [misfolded protein binding] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] GO:1903912 [negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
