Cell atlas - DNAJC3 - The Human Protein Atlas

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DNAJC3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	DNAJC3
Gene description	DnaJ (Hsp40) homolog, subfamily C, member 3
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039336
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039336	A-431	Endoplasmic reticulum
	HPA039336	U-2 OS	Endoplasmic reticulum
	HPA039336	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	DNAJC3 (HGNC Symbol)
Synonyms	HP58, P58, P58IPK, PRKRI
Description	DnaJ (Hsp40) homolog, subfamily C, member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
Chromosome	13
Cytoband	q32.1
Chromosome location (bp)	95677139 - 95794989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102580 (version 83.38)
Entrez gene	5611
UniProt	Q13217 (UniProt - Evidence at protein level)
neXtProt	NX_Q13217
Antibodypedia	DNAJC3 antibodies

PROTEIN BROWSER

DNAJC3-001	DNAJC3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAJC3-001 ENSP00000473631 ENST00000602402	Q13217 [Direct mapping] DnaJ homolog subfamily C member 3 A8KA82 [Target identity:100%; Query identity:100%] DnaJ (Hsp40) homolog, subfamily C, member 3; cDNA FLJ77657, highly similar to Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 3 (DNAJC3), mRNA; cDNA, FLJ93304, Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 3 (DNAJC3),mRNA Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004860 [protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005788 [endoplasmic reticulum lumen] GO:0005790 [smooth endoplasmic reticulum] GO:0016020 [membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0031205 [endoplasmic reticulum Sec complex] GO:0036498 [IRE1-mediated unfolded protein response] GO:0043066 [negative regulation of apoptotic process] GO:0044267 [cellular protein metabolic process] GO:0051087 [chaperone binding] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0051607 [defense response to virus] GO:0051787 [misfolded protein binding] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] GO:1903912 [negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] Show all	504 aa 57.6 kDa	Yes	0
DNAJC3-002 ENSP00000365991 ENST00000376795	X6R9L0 [Direct mapping] DnaJ homolog subfamily C member 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	453 aa 51.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.