Expression of SLC25A15 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15

Protein class

Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042146

GENE INFORMATION
Gene name	SLC25A15 (HGNC Symbol)
Synonyms	D13S327, HHH, ORC1, ORNT1
Description	Solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 (HGNC Symbol)
Entrez gene summary	This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009]
Chromosome	13
Cytoband	q14.11
Chromosome location (bp)	40789412 - 40810111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102743 (version 83.38)
Entrez gene	10166
UniProt	Q9Y619 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y619
Antibodypedia	SLC25A15 antibodies

PROTEIN BROWSER

SLC25A15-001	SLC25A15-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A15-001 ENSP00000415826 ENST00000417731	Q5VZD9 [Direct mapping] Mitochondrial ornithine transporter 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	133 aa 14.4 kDa	No	0
SLC25A15-005 ENSP00000342267 ENST00000338625	Q9Y619 [Direct mapping] Mitochondrial ornithine transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000050 [urea cycle] GO:0000064 [L-ornithine transmembrane transporter activity] GO:0000066 [mitochondrial ornithine transport] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006595 [polyamine metabolic process] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:1903352 [L-ornithine transmembrane transport] Show all	301 aa 32.7 kDa	No	2