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SLC25A15

GENERAL INFORMATION

Gene name

 SLC25A15

Gene description

 Solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Tissue enhanced (liver, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA042146
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, small intestine)

GENE INFORMATION

Gene name

 SLC25A15 (HGNC Symbol)

Synonyms

 D13S327, HHH, ORC1, ORNT1

Description

 Solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009]

Chromosome

 13

Cytoband

 q14.11

Chromosome location (bp)

 40789412 - 40810111

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102743 (version 83.38)

Entrez gene

 10166

UniProt

 Q9Y619 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y619

Antibodypedia

 SLC25A15 antibodies

PROTEIN BROWSER
SLC25A15-001
SLC25A15-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC25A15-001
ENSP00000415826
ENST00000417731
Q5VZD9 [Direct mapping]
Mitochondrial ornithine transporter 1
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
GO:0016021 [integral component of membrane]
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 133 aa
14.4 kDa 		No 0
SLC25A15-005
ENSP00000342267
ENST00000338625
Q9Y619 [Direct mapping]
Mitochondrial ornithine transporter 1
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000050 [urea cycle]
GO:0000064 [L-ornithine transmembrane transporter activity]
GO:0000066 [mitochondrial ornithine transport]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006520 [cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0016021 [integral component of membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:1903352 [L-ornithine transmembrane transport]
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 301 aa
32.7 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.