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ELMO3

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GENERAL INFORMATION

Gene name

 ELMO3

Gene description

 Engulfment and cell motility 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cell junctions.

RNA cell category

 Cell line enhanced (CAPAN-2, T-47d, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cell Junctions (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA021484
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, T-47d, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cell junctions.

Main location

 Plasma membrane (approved), Cell Junctions (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA021484 A-431 Plasma membrane
Cell Junctions
HPA021484 U-2 OS No staining    

GENE INFORMATION

Gene name

 ELMO3 (HGNC Symbol)

Synonyms

 CED-12, CED12, ELMO-3, FLJ13824

Description

 Engulfment and cell motility 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67199111 - 67204029

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102890 (version 83.38)

Entrez gene

 79767

UniProt

 Q96BJ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96BJ8

Antibodypedia

 ELMO3 antibodies

PROTEIN BROWSER
ELMO3-001
ELMO3-002
ELMO3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELMO3-001
ENSP00000354077
ENST00000360833
F8W9E7 [Direct mapping]
Engulfment and cell motility protein 3
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0016477 [cell migration]
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 756 aa
85.3 kDa 		No 0
ELMO3-002
ENSP00000458539
ENST00000477898
Q96BJ8 [Direct mapping]
Engulfment and cell motility protein 3
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
Show all
 607 aa
68.9 kDa 		No 0
ELMO3-003
ENSP00000377566
ENST00000393997
Q96BJ8 [Direct mapping]
Engulfment and cell motility protein 3
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
Show all
 773 aa
87.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.