Cell atlas - LYRM1 - The Human Protein Atlas

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LYRM1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Midbody
	Nucleoplasm

Human cell
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	LYRM1
Gene description	LYR motif containing 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the midbody.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Midbody (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA059840
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the midbody.

Main location

Nucleoplasm (supported)

Additional location

Midbody (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059840	Hep G2	Nucleoplasm
	HPA059840	MCF7	Nucleoplasm
	HPA059840	MCF7	Midbody	Intensity	Intensity
	HPA059840	U-2 OS	Nucleoplasm

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition

GENE INFORMATION
Gene name	LYRM1 (HGNC Symbol)
Synonyms	A211C6.1
Description	LYR motif containing 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	20899868 - 20925006
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102897 (version 83.38)
Entrez gene	57149
UniProt	O43325 (UniProt - Evidence at transcript level)
neXtProt	NX_O43325
Antibodypedia	LYRM1 antibodies

PROTEIN BROWSER

LYRM1-001	LYRM1-002	LYRM1-005	LYRM1-006	LYRM1-008	LYRM1-009	LYRM1-201	LYRM1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LYRM1-001 ENSP00000379367 ENST00000396052	O43325 [Direct mapping] LYR motif-containing protein 1 A0A024R3C2 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0045171 [intercellular bridge] Show all	122 aa 14.3 kDa	No	0
LYRM1-002 ENSP00000396868 ENST00000412082	H3BNA8 [Direct mapping] LYR motif-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 3.8 kDa	No	0
LYRM1-005 ENSP00000454759 ENST00000562740	H3BNA8 [Direct mapping] LYR motif-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 3.8 kDa	No	0
LYRM1-006 ENSP00000457333 ENST00000567954	O43325 [Direct mapping] LYR motif-containing protein 1 A0A024R3C2 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0045171 [intercellular bridge] Show all	122 aa 14.3 kDa	No	0
LYRM1-008 ENSP00000454826 ENST00000568663	O43325 [Direct mapping] LYR motif-containing protein 1 A0A024R3C2 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0045171 [intercellular bridge] Show all	122 aa 14.3 kDa	No	0
LYRM1-009 ENSP00000454551 ENST00000569023	O43325 [Direct mapping] LYR motif-containing protein 1 A0A024R3C2 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0045171 [intercellular bridge] Show all	122 aa 14.3 kDa	No	0
LYRM1-201 ENSP00000219168 ENST00000219168	O43325 [Direct mapping] LYR motif-containing protein 1 A0A024R3C2 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0045171 [intercellular bridge] Show all	122 aa 14.3 kDa	No	0
LYRM1-202 ENSP00000407883 ENST00000439021	O43325 [Direct mapping] LYR motif-containing protein 1 A0A024R3C2 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0045171 [intercellular bridge] Show all	122 aa 14.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.