Expression of DHODH in cancer - Summary

CANCER ATLAS

Gene description

Dihydroorotate dehydrogenase (quinone)

Protein class

Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA010123	HPA011942

GENE INFORMATION
Gene name	DHODH
Synonyms
Description	Dihydroorotate dehydrogenase (quinone) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.2
Chromosome location (bp)	72008588 - 72027664
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102967 (version 83.38)
Entrez gene	1723
UniProt	Q02127 (UniProt - Evidence at protein level)
neXtProt	NX_Q02127
Antibodypedia	DHODH antibodies

PROTEIN BROWSER

DHODH-002	DHODH-003	DHODH-009	DHODH-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHODH-002 ENSP00000461848 ENST00000572887	I3NI32 [Direct mapping] Dihydroorotate dehydrogenase (quinone), mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004152 [dihydroorotate dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process] GO:0006222 [UMP biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0044205 ['de novo' UMP biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	393 aa 42.7 kDa	No	1
DHODH-003 ENSP00000464333 ENST00000576145	J3QRQ3 [Direct mapping] Dihydroorotate dehydrogenase (quinone), mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004152 [dihydroorotate dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0055114 [oxidation-reduction process] Show all	144 aa 16.2 kDa	No	0
DHODH-009 ENSP00000460966 ENST00000574309	I3L449 [Direct mapping] Dihydroorotate dehydrogenase (quinone), mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004152 [dihydroorotate dehydrogenase activity] GO:0005737 [cytoplasm] GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process] GO:0016021 [integral component of membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0055114 [oxidation-reduction process] Show all	193 aa 21.4 kDa	No	1
DHODH-201 ENSP00000219240 ENST00000219240	Q02127 [Direct mapping] Dihydroorotate dehydrogenase (quinone), mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004152 [dihydroorotate dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process] GO:0006222 [UMP biosynthetic process] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0008144 [drug binding] GO:0010181 [FMN binding] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0031000 [response to caffeine] GO:0042493 [response to drug] GO:0042594 [response to starvation] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0044205 ['de novo' UMP biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046134 [pyrimidine nucleoside biosynthetic process] GO:0048039 [ubiquinone binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0090140 [regulation of mitochondrial fission] Show all	395 aa 42.9 kDa	No	1