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DHODH

GENERAL INFORMATION

Gene name

 DHODH

Gene description

 Dihydroorotate dehydrogenase (quinone)

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression. High levels in glandular epithelia, endocrine tissues and in lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA010123 , HPA011942
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 DHODH

Synonyms

Description

 Dihydroorotate dehydrogenase (quinone) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.2

Chromosome location (bp)

 72008588 - 72027664

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102967 (version 83.38)

Entrez gene

 1723

UniProt

 Q02127 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02127

Antibodypedia

 DHODH antibodies

PROTEIN BROWSER
DHODH-002
DHODH-003
DHODH-009
DHODH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHODH-002
ENSP00000461848
ENST00000572887
I3NI32 [Direct mapping]
Dihydroorotate dehydrogenase (quinone), mitochondrial
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004152 [dihydroorotate dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process]
GO:0006222 [UMP biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0044205 ['de novo' UMP biosynthetic process]
GO:0055114 [oxidation-reduction process]
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 393 aa
42.7 kDa 		No 1
DHODH-003
ENSP00000464333
ENST00000576145
J3QRQ3 [Direct mapping]
Dihydroorotate dehydrogenase (quinone), mitochondrial
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004152 [dihydroorotate dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
Show all
 144 aa
16.2 kDa 		No 0
DHODH-009
ENSP00000460966
ENST00000574309
I3L449 [Direct mapping]
Dihydroorotate dehydrogenase (quinone), mitochondrial
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004152 [dihydroorotate dehydrogenase activity]
GO:0005737 [cytoplasm]
GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
Show all
 193 aa
21.4 kDa 		No 1
DHODH-201
ENSP00000219240
ENST00000219240
Q02127 [Direct mapping]
Dihydroorotate dehydrogenase (quinone), mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004152 [dihydroorotate dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process]
GO:0006222 [UMP biosynthetic process]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0008144 [drug binding]
GO:0010181 [FMN binding]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0031000 [response to caffeine]
GO:0042493 [response to drug]
GO:0042594 [response to starvation]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0044205 ['de novo' UMP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046134 [pyrimidine nucleoside biosynthetic process]
GO:0048039 [ubiquinone binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0090140 [regulation of mitochondrial fission]
Show all
 395 aa
42.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.