Cell atlas - PIEZO1 - The Human Protein Atlas

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PIEZO1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	PIEZO1
Gene description	Piezo-type mechanosensitive ion channel component 1
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	PIEZO1 (HGNC Symbol)
Synonyms	FAM38A, KIAA0233
Description	Piezo-type mechanosensitive ion channel component 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	88715343 - 88785211
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103335 (version 83.38)
Entrez gene	9780
UniProt	Q92508 (UniProt - Evidence at protein level)
neXtProt	NX_Q92508
Antibodypedia	PIEZO1 antibodies

PROTEIN BROWSER

PIEZO1-001	PIEZO1-009	PIEZO1-015	PIEZO1-017	PIEZO1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIEZO1-001 ENSP00000301015 ENST00000301015	Q92508 [Direct mapping] Piezo-type mechanosensitive ion channel component 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005261 [cation channel activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0033625 [positive regulation of integrin activation] GO:0033634 [positive regulation of cell-cell adhesion mediated by integrin] GO:0034220 [ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0050982 [detection of mechanical stimulus] GO:0098655 [cation transmembrane transport] Show all	2521 aa 286.8 kDa	No	>9
PIEZO1-009 ENSP00000428673 ENST00000474606	H0YB49 [Direct mapping] Piezo-type mechanosensitive ion channel component 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	182 aa 20.4 kDa	No	0
PIEZO1-015 ENSP00000456680 ENST00000518793	H3BSF6 [Direct mapping] Piezo-type mechanosensitive ion channel component 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	35 aa 3.8 kDa	No	0
PIEZO1-017 ENSP00000456373 ENST00000466823	H3BRR7 [Direct mapping] Piezo-type mechanosensitive ion channel component 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	184 aa 21.5 kDa	No	3
PIEZO1-201 ENSP00000333704 ENST00000327397	E7EUT2 [Direct mapping] Piezo-type mechanosensitive ion channel component 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	373 aa 41.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.