Tissue expression of PIEZO1 - Summary - The Human Protein Atlas

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PIEZO1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PIEZO1
Gene description	Piezo-type mechanosensitive ion channel component 1
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in CNS, including astrocytes.

DATA RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Uncertain based on 1 antibody. HPA047185
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PIEZO1 (HGNC Symbol)
Synonyms	FAM38A, KIAA0233
Description	Piezo-type mechanosensitive ion channel component 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	88715343 - 88785211
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103335 (version 83.38)
Entrez gene	9780
UniProt	Q92508 (UniProt - Evidence at protein level)
neXtProt	NX_Q92508
Antibodypedia	PIEZO1 antibodies

PROTEIN BROWSER

PIEZO1-001	PIEZO1-009	PIEZO1-015	PIEZO1-017	PIEZO1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIEZO1-001 ENSP00000301015 ENST00000301015	Q92508 [Direct mapping] Piezo-type mechanosensitive ion channel component 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005261 [cation channel activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0033625 [positive regulation of integrin activation] GO:0033634 [positive regulation of cell-cell adhesion mediated by integrin] GO:0034220 [ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0050982 [detection of mechanical stimulus] GO:0098655 [cation transmembrane transport] Show all	2521 aa 286.8 kDa	No	>9
PIEZO1-009 ENSP00000428673 ENST00000474606	H0YB49 [Direct mapping] Piezo-type mechanosensitive ion channel component 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	182 aa 20.4 kDa	No	0
PIEZO1-015 ENSP00000456680 ENST00000518793	H3BSF6 [Direct mapping] Piezo-type mechanosensitive ion channel component 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	35 aa 3.8 kDa	No	0
PIEZO1-017 ENSP00000456373 ENST00000466823	H3BRR7 [Direct mapping] Piezo-type mechanosensitive ion channel component 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	184 aa 21.5 kDa	No	3
PIEZO1-201 ENSP00000333704 ENST00000327397	E7EUT2 [Direct mapping] Piezo-type mechanosensitive ion channel component 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	373 aa 41.3 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.