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Cancer tissues displayed moderate to strong nuclear staining with additional cytoplasmic positivity in most of the cases. Membranous staining was observed in colorectal, pancreatic and liver cancers.
GENE INFORMATION
Gene name
SALL1 (HGNC Symbol)
Synonyms
Hsal1, TBS, ZNF794
Description
Spalt-like transcription factor 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000792 [heterochromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001822 [kidney development] GO:0001843 [neural tube closure] GO:0003281 [ventricular septum development] GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007507 [heart development] GO:0008013 [beta-catenin binding] GO:0008406 [gonad development] GO:0010369 [chromocenter] GO:0016575 [histone deacetylation] GO:0016581 [NuRD complex] GO:0021553 [olfactory nerve development] GO:0021772 [olfactory bulb development] GO:0021889 [olfactory bulb interneuron differentiation] GO:0021915 [neural tube development] GO:0021983 [pituitary gland development] GO:0022008 [neurogenesis] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0030325 [adrenal gland development] GO:0031129 [inductive cell-cell signaling] GO:0035136 [forelimb morphogenesis] GO:0035137 [hindlimb morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042733 [embryonic digit morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048566 [embryonic digestive tract development] GO:0060173 [limb development] GO:0061034 [olfactory bulb mitral cell layer development] GO:0072073 [kidney epithelium development] GO:0072092 [ureteric bud invasion] GO:0072309 [mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:2000177 [regulation of neural precursor cell proliferation]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014)