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The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000792 [heterochromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001822 [kidney development] GO:0001843 [neural tube closure] GO:0003281 [ventricular septum development] GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007507 [heart development] GO:0008013 [beta-catenin binding] GO:0008406 [gonad development] GO:0010369 [chromocenter] GO:0016575 [histone deacetylation] GO:0016581 [NuRD complex] GO:0021553 [olfactory nerve development] GO:0021772 [olfactory bulb development] GO:0021889 [olfactory bulb interneuron differentiation] GO:0021915 [neural tube development] GO:0021983 [pituitary gland development] GO:0022008 [neurogenesis] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0030325 [adrenal gland development] GO:0031129 [inductive cell-cell signaling] GO:0035136 [forelimb morphogenesis] GO:0035137 [hindlimb morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042733 [embryonic digit morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048566 [embryonic digestive tract development] GO:0060173 [limb development] GO:0061034 [olfactory bulb mitral cell layer development] GO:0072073 [kidney epithelium development] GO:0072092 [ureteric bud invasion] GO:0072309 [mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:2000177 [regulation of neural precursor cell proliferation]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014)