Cell atlas - TOX3 - The Human Protein Atlas

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TOX3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TOX3
Gene description	TOX high mobility group box family member 3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Cell line enhanced (RT4, AF22, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040376
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, AF22, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040376	Hep G2	Nucleoplasm
	HPA040376	RT4	Nucleoplasm
	HPA040376	U-2 OS	Nucleoplasm
	HPA040376	U-2 OS	Cytosol

GENE INFORMATION
Gene name	TOX3 (HGNC Symbol)
Synonyms	CAGF9, TNRC9
Description	TOX high mobility group box family member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Chromosome	16
Cytoband	q12.1
Chromosome location (bp)	52438005 - 52547802
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103460 (version 83.38)
Entrez gene	27324
UniProt	O15405 (UniProt - Evidence at protein level)
neXtProt	NX_O15405
Antibodypedia	TOX3 antibodies

PROTEIN BROWSER

TOX3-002	TOX3-003	TOX3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TOX3-002 ENSP00000385705 ENST00000407228	O15405 [Direct mapping] TOX high mobility group box family member 3 Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Show all	GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0034056 [estrogen response element binding] GO:0042803 [protein homodimerization activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0051219 [phosphoprotein binding] Show all	571 aa 63.1 kDa	No	0
TOX3-003 ENSP00000219746 ENST00000219746	O15405 [Direct mapping] TOX high mobility group box family member 3 Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Show all	GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0034056 [estrogen response element binding] GO:0042803 [protein homodimerization activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0051219 [phosphoprotein binding] Show all	576 aa 63.3 kDa	No	0
TOX3-004 ENSP00000457401 ENST00000563091	H3BTZ9 [Direct mapping] TOX high mobility group box family member 3 Show all	Predicted intracellular proteins Show all	GO:0006338 [chromatin remodeling] Show all	166 aa 17.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.