Cell atlas - SLC6A2 - The Human Protein Atlas

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SLC6A2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria

Human cell
	Cytosol
	Mitochondria

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GENERAL INFORMATION
Gene name	SLC6A2
Gene description	Solute carrier family 6 (neurotransmitter transporter), member 2
Protein class	Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the mitochondria.
RNA cell category	Cell line enriched (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA004057
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the mitochondria.

Main location

Cytosol (approved)

Additional location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA004057	HaCaT	Mitochondria	Intensity
	HPA004057	HaCaT	Cytosol
	HPA004057	SH-SY5Y	Cytosol
	HPA004057	U-2 OS	No staining

GENE INFORMATION
Gene name	SLC6A2 (HGNC Symbol)
Synonyms	NAT1, NET, NET1, SLC6A5
Description	Solute carrier family 6 (neurotransmitter transporter), member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Chromosome	16
Cytoband	q12.2
Chromosome location (bp)	55655604 - 55706192
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103546 (version 83.38)
Entrez gene	6530
UniProt	P23975 (UniProt - Evidence at protein level)
neXtProt	NX_P23975
Antibodypedia	SLC6A2 antibodies

PROTEIN BROWSER

SLC6A2-001	SLC6A2-003	SLC6A2-004	SLC6A2-005	SLC6A2-006	SLC6A2-007	SLC6A2-008	SLC6A2-009	SLC6A2-010	SLC6A2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC6A2-001 ENSP00000369237 ENST00000379906	P23975 [Direct mapping] Sodium-dependent noradrenaline transporter A0A024R6T9 [Target identity:100%; Query identity:100%] Transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005334 [norepinephrine:sodium symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006836 [neurotransmitter transport] GO:0007268 [synaptic transmission] GO:0008504 [monoamine transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015874 [norepinephrine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043005 [neuron projection] GO:0055085 [transmembrane transport] Show all	617 aa 69.3 kDa	No	>9
SLC6A2-003 ENSP00000394956 ENST00000414754	H3BM11 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	561 aa 62.9 kDa	No	>9
SLC6A2-004 ENSP00000457473 ENST00000568943	P23975 [Direct mapping] Sodium-dependent noradrenaline transporter A0A024R6T9 [Target identity:100%; Query identity:100%] Transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005334 [norepinephrine:sodium symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006836 [neurotransmitter transport] GO:0007268 [synaptic transmission] GO:0008504 [monoamine transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015874 [norepinephrine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043005 [neuron projection] GO:0055085 [transmembrane transport] Show all	617 aa 69.3 kDa	No	>9
SLC6A2-005 ENSP00000457375 ENST00000567238	P23975 [Direct mapping] Sodium-dependent noradrenaline transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005334 [norepinephrine:sodium symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006836 [neurotransmitter transport] GO:0007268 [synaptic transmission] GO:0008504 [monoamine transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015874 [norepinephrine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043005 [neuron projection] GO:0055085 [transmembrane transport] Show all	512 aa 57.4 kDa	No	>9
SLC6A2-006 ENSP00000456210 ENST00000566163	H3BRE9 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	572 aa 64.3 kDa	No	>9
SLC6A2-007 ENSP00000454439 ENST00000561820	H3BML6 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005887 [integral component of plasma membrane] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	604 aa 67.7 kDa	No	>9
SLC6A2-008 ENSP00000454603 ENST00000568655	H3BMY5 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	200 aa 22.4 kDa	No	3
SLC6A2-009 ENSP00000456377 ENST00000568529	H3BRS0 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005887 [integral component of plasma membrane] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	295 aa 33.2 kDa	No	5
SLC6A2-010 ENSP00000460214 ENST00000574918	I3L368 [Direct mapping] Sodium-dependent noradrenaline transporter Show all	Predicted intracellular proteins Show all		58 aa 6.3 kDa	No	0
SLC6A2-201 ENSP00000219833 ENST00000219833	P23975 [Direct mapping] Sodium-dependent noradrenaline transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005334 [norepinephrine:sodium symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006836 [neurotransmitter transport] GO:0007268 [synaptic transmission] GO:0008504 [monoamine transmembrane transporter activity] GO:0015844 [monoamine transport] GO:0015874 [norepinephrine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043005 [neuron projection] GO:0048265 [response to pain] GO:0055085 [transmembrane transport] Show all	628 aa 70.5 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.